Today I’m going to share some very important information with you. As you know, dermatology offers dozens of aesthetic procedures. Recent data from the American Society of Plastic Surgeons shows that minimally invasive aesthetic procedures increased by more than 150% over the past two decades, highlighting the growing demand for quick, effective cosmetic enhancements. Among these treatments, the four most sought-after by patients continue to be Botox injections, dermal fillers, chemical peels, and laser hair removal, driven by their proven results and minimal downtime.
Não perca a dica do Dr. Szerman ao final do artigo!
However, there are four treatments that I perform the most in my office, which are definitely the most effective and offer the best cost-benefit ratio for patients. Check them out below and discover which aesthetic procedures are the most sought-after and their benefits.
The Most Popular Aesthetic Procedures – CO2 Laser
The CO2 Laser is considered in any dermatology textbook as one of the gold-standard, non-surgical aesthetic procedures for skin rejuvenation. It acts on spots, acne scars, melasma, and expression lines, restoring firmness and radiance by stimulating collagen production.
It’s a highly comprehensive treatment. Among the main benefits are improved skin texture and firmness, reduction of wrinkles, acne scars, spots, and enlarged pores. The treatment also contributes to a younger, more even skin appearance.
With visible results after just a few sessions, CO2 laser is recommended for those seeking revitalized, healthy-looking skin. It should always be performed under the guidance of a specialized professional.
The Most Popular Aesthetic Procedures – Botulinum Toxin
Second among the most sought-after aesthetic procedures is botulinum toxin. When a patient has expression lines and strong muscle activity in the upper third of the face, botulinum toxin is the perfect fit.
This procedure temporarily blocks the contraction of the muscles responsible for expression lines. By being applied to specific points, it prevents the release of acetylcholine, the neurotransmitter that stimulates muscle contraction. As a result, the muscles relax, softening dynamic wrinkles such as those on the forehead, glabella, and around the eyes.
Patients who try it for the first time usually love the result, as botulinum toxin relieves facial expressions while also providing a subtle lift to the eyes.
The effects can be noticed in just a few days, with the best results appearing after about two weeks. In addition to cosmetic uses, botulinum toxin is also used for therapeutic treatments such as migraines and bruxism. It is a quick, safe, and minimally invasive procedure.
The Most Popular Aesthetic Procedures – MD Codes
In third place is MD Codes. Many patients come to the office afraid of looking too “full” or volumized. Unfortunately, this happens because in many places, practitioners simply add volume to the face. But the MD Codes technique is not about volume.
This method consists of strategically placing hyaluronic acid fillers in specific points of the face to bring support and lift — without plastic surgery.
By mapping precise facial points, fillers are applied to restore lost volume, enhance facial contours, and smooth wrinkles, all while maintaining a natural look.
The approach also considers the emotions conveyed by facial expressions, aiming for a more balanced and expressive appearance.
It is minimally invasive, performed in-office, with immediate and progressive results that last from two to four years.
Collagen Biostimulators

In fourth place are collagen biostimulators. These are minimally invasive procedures that, once applied into the skin, stimulate natural collagen production.
Unlike fillers, they don’t add immediate volume, but instead act progressively, offering natural and long-lasting results.
Collagen Biostimulators with CO2 Laser
When combined, especially with CO2 laser (a physical stimulus), collagen biostimulators (a chemical stimulus) deliver even better results.
I often compare CO2 laser to taking the patient’s skin to the gym — and then giving it back renewed. The collagen biostimulator, in this analogy, works like taking a high-quality supplement (like whey protein) right after a workout.
This combination — a physical stimulus with a chemical one — is truly the best of both worlds, and patients simply love the outcome.
Do collagen biostimulators bring results on their own? Absolutely. But when combined with CO2 laser, studies show that results can be amplified six or even seven times.
It is a minimally invasive, safe procedure, recommended for those who want a younger, healthier look without losing naturalness.
What Are the Best Facial Aesthetic Procedures for Rejuvenation?
With the advancement of aesthetics, facial rejuvenation without surgery is increasingly possible — and highly desirable. But what are the best treatments for achieving a younger, natural appearance?
Among the favorites is Botox, which smooths expression lines by preventing muscle contraction, giving a more relaxed, wrinkle-free look. Hyaluronic acid fillers restore volume lost over time, redefining areas such as cheeks, under-eyes, and lips.
Another highlight is collagen biostimulators, which work from the inside out, stimulating natural collagen production to improve firmness and elasticity.
Finally, chemical peels and fractional/pulsed lasers are excellent for skin renewal, reducing pigmentation, and boosting collagen.
The secret lies in personalized assessment. A good professional will recommend the most suitable procedures for your skin type and goals. Rejuvenating naturally is possible — and it starts with the right choice.
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Clínica de Pele has specialized in dermatological treatments in Rio de Janeiro for over 60 years, since 1969. Dr. Szerman has more than 20 years of experience and also teaches other physicians.



